Erratum

Fred R. Shapiro and Michelle Pearse\u27s essay The Most-Cited Law Review Articles of All Time, 110 MICH. L. REV. 1483 (2012), omitted an article: Owen M. Fiss, Groups and the Equal Protection Clause, 5 PHIL. & PUB. AFF. 107 (1976). Professor Fiss\u27s article should have been listed in 72nd place (with 729 citations) in Table I, Most-Cited Law Review Articles of All Time. Professor Fiss\u27s article fell into the category of articles published in nonlegal journals with over 50 percent of the citations to them occurring in legal journals. See Shapiro & Pearse, supra, at 1487-88. This category by its nature was impossible for Mr. Shapiro to capture completely. With this correction, Professor Fiss enters into a tie with Frank Michelman as the only scholars with four articles on the all-time list

Predicting the sound insulation of plywood panels when treated with decoupled mass loaded barriers

The addition of mass loaded barriers can be used to improve the sound transmission loss properties of lightweight panels. Decoupling of the mass layer from the panel is achieved using a layer of open celled foam. This treatment causes the panel system to exhibit sound transmission loss behaviour that is similar to conventional double leaf walls. The effects of altering the thickness of the decoupling foam layer, the surface density of the barrier, and the attachment between the treatment and the panel were assessed experimentally. Several analytical prediction methods were combined to develop a model for the transmission loss of the treated system. The material properties of the panel and treatment were measured using static and dynamic methods. These measured values were used in the prediction methods. The prediction methods yielded a range of agreements with the experimental results. The quality of agreement was found to depend on the thickness of the foam decoupling layer, the surface density of the barrier layer and most significantly the attachment method

The sound insulation of single leaf finite size rectangular plywood panels with orthotropic frequency dependent bending stiffness

Current theories for predicting the sound insulation of orthotropic materials are limited to a small range of infinite panels. This paper presents a method that allows for the prediction of the sound insulation of a finite size orthotropic panel. This method uses an equation for the forced radiation impedance of a finite size rectangular panel. This approach produces an equation that has three nested integrals. The long numerical calculation times were reduced by using approximate formulas for the azimuthally averaged forced radiation impedance. This reduced the number of nested integrals from three to two. The resulting predictions are compared to results measured using two sample sizes of four different thicknesses of plywood and one sample size of another three different thicknesses of plywood. Plywood was used for all the tests because it is somewhat orthotropic. It was found during testing that the Young's moduli of the plywood were dependent on the frequency of excitation. The influence of the frequency dependent Young's moduli was then included in the prediction method. The experimental results were also compared with a simple isotropic prediction method

Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians

Angiogenesis is the process by which new blood vessels form from existing vessel networks. In the past three decades, significant progress has been made in our understanding of angiogenesis; progress driven in large part by the increasing realization that blood vessel growth can promote or facilitate disease. By the early 1990s, it had become clear that the recently discovered “vascular endothelial growth factor” (VEGF) was a powerful mediator of angiogenesis. As a result, several groups targeted this molecule as a potential mediator of retinal ischemia-induced neovascularization in disorders such as diabetic retinopathy and retinal vein occlusion. Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD). Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization. In this review, we provide a guide for clinicians on the development of anti-VEGF therapies for intraocular use

Prevention of postoperative pulmonary complications in the hypoxaemic patient - gathering the evidence for noninvasive respiratory support

This is the accepted manuscript of article published in European Journal of Anaesthesiology. The final published version is available online at doi: 10.1097/EJA.000000000000118

Retinal vein occlusion and macular edema – critical evaluation of the clinical value of ranibizumab

Retinal vein occlusions (RVOs) constitute the second most common cause of retinal vascular disease after diabetic retinopathy, with a prevalence of between 1% and 2% in persons older than 40 years of age. Despite the existence of numerous potential therapeutic options, none is entirely satisfactory, and many patients with RVO suffer irreversible visual loss. Fortunately however, the recent introduction of antivascular endothelial growth factor (VEGF) agents, such as ranibizumab (Lucentis®, Genentech, South San Francisco, CA) and bevacizumab (Avastin®, Genentech), offers a potentially new treatment approach for clinicians managing this disorder. The results of the BRAVO and CRUISE trials have provided the first definitive evidence for the efficacy and safety of ranibizumab in the treatment of RVO. As a result, ranibizumab has recently been approved by the US Food and Drug Administration for the treatment of RVO-associated macular edema. In this review, we provide a critical evaluation of clinical trial data for the safety and efficacy of ranibizumab, and address unresolved issues in the management of this disorder

The average specific forced radiation wave impedance of a finite rectangular panel

The average specific forced radiation wave impedance of a finite rectangular panel is of importance for the prediction of both sound insulation and sound absorption. In 1982, Thomasson published numerical calculations of the average specific forced radiation wave impedance of a square of side length 2e for wave number k in half octave steps of ke from 0.25 to 64. Thomasson's calculations were for the case when the forced bending wave number kb was less than or equal to k. Thomasson also published approximate formulas for values of ke above and below the published results. This paper combines Thomasson's high and low frequency formulas and compares this combined formula with Thomasson's numerical calculations. The real part of the approximate formula is between 0.7 dB higher and -1 dB lower than the numerical calculations. The imaginary part of the approximate formula is between 2.3 dB higher and -2.6 dB lower than the numerical calculations. This paper also gives approximate formulas for the case when kb is greater than or equal to k. The differences are between 0.8 and -1.2 dB for the imaginary part and between 6.2 and -2.4 dB for the real part

The acoustic radiation impedance of a rectangular panel

This paper extends the definition of the one sided radiation impedance of a panel mounted in an infinite rigid baffle which was previously used by the authors so that it can be applied to all transverse velocity wave types on the panel rather than just to the possibly forced travelling plane transverse velocity waves considered previously by the authors. For the case of travelling plane waves on a rectangular panel with anechoic edge conditions, and for the case of standing waves on a rectangular panel with simply supported edge conditions, the equations resulting from one of the standard reductions from quadruple to double integrals are given. These double integral equations can be reduced to single integral equations, but the versions of these equations given in the literature did not always converge when used with adaptive integral routines and were sometimes slower than the double integral versions. This is because the terms in the integrands in the existing equations have singularities. Although these singularities cancel, they caused problems for the adaptive integral routines. This paper rewrites these equations in a form which removes the singularities and enables the integrals in these equations to be evaluated with adaptive integral routines. Approximate equations for the azimuthally averaged one sided radiation impedance of a rectangular panel mounted in an infinite baffle are given for all the cases considered in this paper and the values produced by these equations are compared with numerical calculations

Pre-specification of statistical analysis approaches in published clinical trial protocols was inadequate

OBJECTIVES: Results from randomized trials can depend on the statistical analysis approach used. It is important to prespecify the analysis approach in the trial protocol to avoid selective reporting of analyses based on those which provide the most favourable results. We undertook a review of published trial protocols to assess how often the statistical analysis of the primary outcome was adequately prespecified. METHODS: We searched protocols of randomized trials indexed in PubMed in November 2016. We identified whether the following aspects of the statistical analysis approach for the primary outcome were adequately prespecified: (1) analysis population; (2) analysis model; (3) use of covariates; and (4) method of handling missing data. RESULTS: e identified 99 eligible protocols. Very few protocols adequately prespecified the analysis population (8/99, 8%), analysis model (27/99, 27%), covariates (40/99, 40%), or approach to handling missing data (10/99, 10%). Most protocols did not adequately predefine any of these four aspects of their statistical analysis approach (39%) or predefined only one aspect (36%). No protocols adequately predefined all four aspects of the analysis. CONCLUSION: The statistical analysis approach is rarely prespecified in published trial protocols. This may allow selective reporting of results based on different analyses

Clinical review: How to optimize management of high-risk surgical patients

For many patients optimal perioperative care may require little or no additional medical management beyond that given by the anaesthetist and surgeon. However, the continued existence of a group of surgical patients at high risk for morbidity and mortality indicates an ongoing need to identify such patients and deliver optimal care throughout the perioperative period. A group of patients exists in whom the risk for death and serious complications after major surgery is in excess of 20%. The risk is related mainly to the patient's preoperative physiological condition and, in particular, the cardiovascular and respiratory reserves. Cardiovascular management of the high-risk surgical patient is of particular importance. Once the medical management of underlying disease has been optimized, two principal areas remain: the use of haemodynamic goals to guide fluid and inotropic therapy, and perioperative β blockade. A number of studies have shown that the use of goal-directed haemodynamic therapy during the perioperative period can result in large reductions in morbidity and mortality. Some patients may also benefit from perioperative β blockade, which in selected patients has also been shown to result in significant mortality reductions. In this review a pragmatic approach to perioperative management is described, giving guidance on the identification of the high-risk patient and on the use of goal-directed haemodynamic therapy and β blockade